Annexins-a family of proteins with distinctive tastes for cell signaling and membrane dynamics.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 38383560.
- Also identified by DOI 10.1038/s41467-024-45954-0 and PMC identifier 10882027.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Annexins are cytosolic proteins with conserved three-dimensional structures that bind acidic phospholipids in cellular membranes at elevated Ca<sup>2+</sup> levels. Through this they act as Ca<sup>2+</sup>-regulated membrane binding modules that organize membrane lipids, facilitating cellular membrane transport but also displaying extracellular activities. Recent discoveries highlight annexins as sensors and regulators of cellular and organismal stress, controlling inflammatory reactions in mammals, environmental stress in plants, and cellular responses to plasma membrane rupture. Here, we describe the role of annexins as Ca<sup>2+</sup>-regulated membrane binding modules that sense and respond to cellular stress and share our view on future research directions in the field.
Medical subject headings
- Annexins
- Taste