Gene editing: a near future for the treatment of genetic kidney diseases.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 38388140.
- Also identified by DOI 10.1016/j.kint.2024.01.004.
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Abstract
The study by Chen et al. is the first to apply the revolutionary genetic engineering tool, base editing, in a rat model for the treatment of primary hyperoxaluria type 1, a disease that originates in the liver but in which the kidney is the main organ affected. This commentary contextualizes and describes the gene-editing technology applied by the authors, provides an interpretation and opinion of their results, and indicates possible future applications.
Medical subject headings
- Gene Editing
- Kidney Diseases