A Hangover Under 177 Lu-PSMA-617 Therapy : A Red Flag for Brain 68 Ga-PSMA-11 PET/MRI?
case_report · Level V
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- Record sourced from PubMed, PMID 38389216.
- Also identified by DOI 10.1097/RLU.0000000000005126.
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Abstract
Leptomeningeal carcinomatosis in prostate cancer is extremely rare. Because of the low overall penetration of drugs into the brain and the prolonged survival of castration-resistant prostate cancer (CRPC) patients, a special attention should be paid to the appearance of neurological symptoms in long-term CRPC survivors. A patient suffering from a CRPC with bone metastases underwent 4 cycles of 177 Lu-PSMA (prostate-specific membrane antigen)-617. Starting from the third cycle, he reported an increasing feeling of a permanent hangover. A 68 Ga-PSMA-11 brain PET/MRI was carried out after the fourth cycle. It revealed intraparenchymatous brain metastases with intense uptake and evidences of leptomeningeal carcinomatosis.
Medical subject headings
- Gallium Isotopes
- Gallium Radioisotopes
- Magnetic Resonance Imaging
- Lutetium
- Positron-Emission Tomography
- Prostate-Specific Antigen