Role of the Exposome in Neurodegenerative Disease: Recent Insights and Future Directions.
review · Level V
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- Record sourced from PubMed, PMID 38411261.
- Also identified by DOI 10.1002/ana.26897 and PMC identifier 11023772.
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Abstract
Neurodegenerative diseases are increasing in prevalence and place a significant burden on society. The causes are multifactorial and complex, and increasing evidence suggests a dynamic interplay between genes and the environment, emphasizing the importance of identifying and understanding the role of lifelong exposures, known as the exposome, on the nervous system. This review provides an overview of recent advances toward defining neurodegenerative disease exposomes, focusing on Parkinson's disease, amyotrophic lateral sclerosis, and Alzheimer's disease. We present the current state of the field based on emerging data, elaborate on key themes and potential mechanisms, and conclude with limitations and future directions. ANN NEUROL 2024;95:635-652.
Medical subject headings
- Neurodegenerative Diseases
- Exposome
- Alzheimer Disease
- Parkinson Disease