Combined Protection of Vaccination and Nirmatrelvir-Ritonavir Against Hospitalization in Adults With COVID-19.

Shah, Melisa M; Joyce, Brendan; Plumb, Ian D; Sahakian, Sam; Feldstein, Leora R; Barkley, Eric; Paccione, Mason; Deckert, Joseph et al. · Clin Infect Dis · 2024

retrospective_cohort · Level III

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Abstract

Among adults at risk for severe coronavirus disease 2019 (COVID-19), the lowest hospitalization rate was among those who received nirmatrelvir-ritonavir after 3 or more messenger RNA vaccine doses (adjusted hazard ratio, 0.22; 95% confidence interval, .19-.24). Eligible adults, including those previously vaccinated, should be considered for COVID-19 antiviral treatment.

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