All That Is Small Is Not a Small-Cell Carcinoma: Thoracic SMARCA4-Deficient Undifferentiated Tumors Masquerading as SCLC.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 38416596.
- Also identified by DOI 10.1158/1078-0432.CCR-24-0227.
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Abstract
Small-cell lung carcinoma (SCLC) cell lines have been widely utilized as a preclinical model of this highly aggressive disease. However, since their creation decades ago, novel tumor entities have been defined that might clinicopathologically mimic SCLC, which notably includes thoracic SMARCA4-deficient undifferentiated tumor (SMARCA4-UT). Multiomic reassessment of the presumed SCLC cell lines with high YAP1 expression reveals that nearly all of these tumors represent unsuspected SMARCA4-UT. See related article by Ng et al., p. 1846.
Medical subject headings
- DNA Helicases
- Small Cell Lung Carcinoma
- Transcription Factors
- Nuclear Proteins
- Lung Neoplasms