Cellular reprogramming as a tool to model human aging in a dish.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 38418829.
- Also identified by DOI 10.1038/s41467-024-46004-5 and PMC identifier 10902382.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
The design of human model systems is highly relevant to unveil the underlying mechanisms of aging and to provide insights on potential interventions to extend human health and life span. In this perspective, we explore the potential of 2D or 3D culture models comprising human induced pluripotent stem cells and transdifferentiated cells obtained from aged or age-related disorder-affected donors to enhance our understanding of human aging and to catalyze the discovery of anti-aging interventions.
Medical subject headings
- Induced Pluripotent Stem Cells