The multivisceral landscape of colorectal cancer metastasis: implications for targeted therapies.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 38426495.
- Also identified by DOI 10.1172/JCI178331 and PMC identifier 10904034.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Colorectal cancer (CRC) is among the most common cancer types and the second deadliest malignancy for both sexes. Metastatic disease poses substantial therapeutic challenges, and peritoneal spread, in particular, reduces quality of life and has a dismal outcome. In this issue of the JCI, Berlin and authors have made considerable advancements in understanding the cellular and molecular composition of multivisceral CRC metastasis in a sophisticated murine orthotopic organoid model and in humans. The study provides unprecedented insights into the complex biology of the disease and points toward the development of compartmentalized immune-therapeutic strategies.
Medical subject headings
- Quality of Life
- Colorectal Neoplasms