A role for TMEM63 in the lung.
editorial · Level V
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- Record sourced from PubMed, PMID 38426500.
- Also identified by DOI 10.1172/JCI178948 and PMC identifier 10904035.
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Abstract
Surfactants are essential for breathing. Although major progress has been made in the past half century toward an understanding of surfactant secretion mechanisms, the identity of the mechanosensor that couples breathing to surfactant secretion has remained elusive. In this issue of the JCI, Chen, Li, and colleagues provide evidence that the mechanosensor is the transmembrane 63 (TMEM63) ion channel. These findings open new avenues for future research into lung mechanobiology.
Medical subject headings
- Lung
- Pulmonary Surfactants