NETs unleashed: neutrophil extracellular traps boost chemotherapy against colorectal cancer.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 38426501.
- Also identified by DOI 10.1172/JCI178344 and PMC identifier 10904039.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Chemotherapy, which primarily acts on cancer cells, can influence the tumor microenvironment and the recruitment and behavior of stromal cells. In this issue of the JCI, Li et al. explored the potent anticancer effect of the combination of a glutaminase inhibitor (CB-839) and 5-FU against PIK3CA-mutant colorectal cancer tumors. This chemotherapy treatment strongly induced the recruitment of neutrophils that formed neutrophil extracellular traps in cancer, which actively killed cancer cells by inducing apoptosis. This study substantially advances our understanding of the multifaceted role of neutrophils and NETs in the outcome of anticancer treatment.
Medical subject headings
- Extracellular Traps
- Colorectal Neoplasms