Epigenetic aging of human blood cells is influenced by the age of the host body.
Where this comes from
- Record sourced from PubMed, PMID 38439206.
- Also identified by DOI 10.1111/acel.14112 and PMC identifier 11113269.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Allogenic hematopoietic stem cell transplantation is a therapeutic procedure performed over a wide range of donor and recipient age combinations, representing natural experiments of how the age of the recipient affects aging in transplanted donor cells in vivo. We measured DNA methylation and epigenetic aging in donors and recipients and found that biological epigenetic clocks are accelerated in cells transplanted into an older body and decelerated in a younger body. This is the first evidence that the age of the circulating environment influences human epigenetic aging in vivo.
Medical subject headings
- Epigenesis, Genetic
- DNA Methylation
- Cellular Senescence
- Aging