Carnosine facilitates lysosomal release of inhibitors of T cell surveillance.
basic_science · Level V
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- Record sourced from PubMed, PMID 38447528.
- Also identified by DOI 10.1016/j.cmet.2024.02.003.
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Abstract
Cancer metabolism produces large fluxes of lactate and H<sup>+</sup>, which are extruded by membrane transporters. However, H<sup>+</sup> production and extrusion must be coupled by diffusion, facilitated by mobile buffers. Yan et al. propose that carnosine, generated by CARNS2, provides this mobile buffering and enables lysosomal functions that block T cell surveillance.
Medical subject headings
- Carnosine