Supercharging cancer-fighting T cells with lithium carbonate.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 38447529.
- Also identified by DOI 10.1016/j.cmet.2024.02.006.
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Abstract
Lactate influences the behavior of various immune cell types. In a recent Nature Immunology study, Ma et al. revealed that lithium carbonate induces monocarboxylate transporter 1 translocation to mitochondria, enhancing cytoplasmic lactate transport into the mitochondria and increasing lactate mitochondrial metabolism, thereby promoting T cell effector function.
Medical subject headings
- Lithium Carbonate
- Neoplasms