Perirenal adipose tissue contains a subpopulation of cold-inducible adipocytes derived from brown-to-white conversion.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 38470102.
- Also identified by DOI 10.7554/eLife.93151 and PMC identifier 10932542.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Perirenal adipose tissue (PRAT) is a unique visceral depot that contains a mixture of brown and white adipocytes. The origin and plasticity of such cellular heterogeneity remains unknown. Here, we combine single-nucleus RNA sequencing with genetic lineage tracing to reveal the existence of a distinct subpopulation of <i>Ucp1</i><sup>-</sup>&<i>Cidea</i><sup>+</sup> adipocytes that arises from brown-to-white conversion during postnatal life in the periureter region of mouse PRAT. Cold exposure restores <i>Ucp1</i> expression and a thermogenic phenotype in this subpopulation. These cells have a transcriptome that is distinct from subcutaneous beige adipocytes and may represent a unique type of cold-recruitable adipocytes. These results pave the way for studies of PRAT physiology and mechanisms controlling the plasticity of brown/white adipocyte phenotypes.
Medical subject headings
- Adipose Tissue
- Adipocytes, Beige