Harnessing regulatory T cells to establish immune tolerance.

Ho, Patrick; Cahir-McFarland, Ellen; Fontenot, Jason D; Lodie, Tracey; Nada, Adel; Tang, Qizhi; Turka, Laurence A; Bluestone, Jeffrey A · Sci Transl Med · 2024

review · Level V

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Abstract

Engineered regulatory T (T<sub>reg</sub>) cells have emerged as precision therapeutics aimed at inducing immune tolerance while reducing the risks associated with generalized immunosuppression. This Viewpoint highlights the opportunities and challenges for engineered T<sub>reg</sub> cell therapies in treating autoimmune and other inflammatory diseases.

Medical subject headings