RN7SL1 may be translated under oncogenic conditions.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 38478683.
- Also identified by DOI 10.1073/pnas.2312322121 and PMC identifier 10962956.
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Abstract
RN7SL1 (RNA component of signal recognition particle 7SL1), a component of the signal recognition particle, is a non-coding RNA possessing a small ORF (smORF). However, whether it is translated into peptides is unknown. Here, we generated the RN7SL1-Green Fluorescent Protein (GFP) gene, in which the smORF of RN7SL1 was replaced by GFP, introduced it into 293T cells, and observed cells emitting GFP fluorescence. Furthermore, RNA-seq of GFP-positive cells revealed that they were in an oncogenic state, suggesting that RN7SL1 smORF may be translated under special conditions.
Medical subject headings
- Signal Recognition Particle
- Peptides