Effectiveness of Tofacitinib in Patients With Ulcerative Colitis: A Nationwide Veterans Administration Cohort Study.
retrospective_cohort · Level III
Where this comes from
- Record sourced from PubMed, PMID 38483302.
- Also identified by DOI 10.14309/ajg.0000000000002761 and PMC identifier 11288386.
- Licence recorded as CC BY-NC-ND.
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Abstract
There is paucity of data on the effectiveness and safety of tofacitinib among elderly patients with ulcerative colitis (UC). Through a retrospective cohort study among the US National Veterans Affairs Healthcare System, we evaluated effectiveness among the elderly (≥65) and young (<65) patients with UC initiated on tofacitinib. Among 158 patients (53 elderly, 105 young), effectiveness at 12 months was 50.94% in the elderly and 33.33% in the young ( P = 0.032). In a nationwide cohort of patients with UC initiating tofacitinib, effectiveness was seen in half of the elderly patients.