longmixr: a tool for robust clustering of high-dimensional cross-sectional and longitudinal variables of mixed data types.

Hagenberg, Jonas; Budde, Monika; Pandeva, Teodora; Kondofersky, Ivan; Schaupp, Sabrina K; Theis, Fabian J; Schulze, Thomas G; Müller, Nikola S et al. · Bioinformatics · 2024

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Abstract

Accurate clustering of mixed data, encompassing binary, categorical, and continuous variables, is vital for effective patient stratification in clinical questionnaire analysis. To address this need, we present longmixr, a comprehensive R package providing a robust framework for clustering mixed longitudinal data using finite mixture modeling techniques. By incorporating consensus clustering, longmixr ensures reliable and stable clustering results. Moreover, the package includes a detailed vignette that facilitates cluster exploration and visualization. The R package is freely available at https://cran.r-project.org/package=longmixr with detailed documentation, including a case vignette, at https://cellmapslab.github.io/longmixr/.

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