Graphene Oxide Membrane Reactor for Electrochemical Deuteration Reactions.
basic_science · Level V
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- Record sourced from PubMed, PMID 38489112.
- Also identified by DOI 10.1021/acs.nanolett.3c04243.
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Abstract
The deuteration of organic molecules is considerably important in organic and medicinal chemistry. An electrochemical membrane reactor using proton-conducting graphene oxide (GO) nanosheets was developed to synthesize valuable deuterium-labeled products via an efficient hydrogen-to-deuterium (H/D) exchange under mild conditions at ambient temperature and atmospheric pressure. Deuterons (D<sup>+</sup>) formed by the anodic oxidation of heavy water (D<sub>2</sub>O) at the Pt/C anode permeate through the GO membrane to the Pt/C cathode, where organic molecules with functional groups (C≡C and C═O) are deuterated with adsorbed atomic D species. Deuteration occurs in outstanding yields with high levels of D incorporation. We also achieved the electrodeuteration of a drug molecule, ibuprofen, demonstrating the promising feasibility of the GO membrane reactor in the pharmaceutical industry.