Pyroptotic T cell-derived active IL-16 has a driving function in ovarian endometriosis development.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 38508138.
- Also identified by DOI 10.1016/j.xcrm.2024.101476 and PMC identifier 10983113.
- Licence recorded as CC BY-NC-ND.
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Abstract
Endometriosis, affecting 6%-10% of women, often leads to pain and infertility and its underlying inflammatory mechanisms are poorly understood. We established endometriosis models in wild-type and IL16KO mice, revealing the driver function of IL-16 in initiating endometriosis-related inflammation. Using an in vitro system, we confirmed iron overload-induced GSDME-mediated pyroptosis as a key trigger for IL-16 activation and release. In addition, our research led to the development of Z30702029, a compound inhibiting GSDME-NTD-mediated pyroptosis, which shows promise as a therapeutic intervention for endometriosis. Importantly, our findings extend beyond endometriosis, highlighting GSDME-mediated pyroptosis as a broader pathway for IL-16 release and offering insights into potential treatments for various inflammatory conditions.
Medical subject headings
- Endometriosis