Artificial cells for in vivo biomedical applications through red blood cell biomimicry.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 38509073.
- Also identified by DOI 10.1038/s41467-024-46732-8 and PMC identifier 10954685.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Recent research in artificial cell production holds promise for the development of delivery agents with therapeutic effects akin to real cells. To succeed in these applications, these systems need to survive the circulatory conditions. In this review we present strategies that, inspired by the endurance of red blood cells, have enhanced the viability of large, cell-like vehicles for in vivo therapeutic use, particularly focusing on giant unilamellar vesicles. Insights from red blood cells can guide modifications that could transform these platforms into advanced drug delivery vehicles, showcasing biomimicry's potential in shaping the future of therapeutic applications.
Medical subject headings
- Artificial Cells