Alcohol-alcohol cross-coupling enabled by S<sub>H</sub>2 radical sorting.
basic_science · Level V
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- Record sourced from PubMed, PMID 38513032.
- Also identified by DOI 10.1126/science.adl5890 and PMC identifier 11551712.
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Abstract
Alcohols represent a functional group class with unparalleled abundance and structural diversity. In an era of chemical synthesis that prioritizes reducing time to target and maximizing exploration of chemical space, harnessing these building blocks for carbon-carbon bond-forming reactions is a key goal in organic chemistry. In particular, leveraging a single activation mode to form a new C(sp<sup>3</sup>)-C(sp<sup>3</sup>) bond from two alcohol subunits would enable access to an extraordinary level of structural diversity. In this work, we report a nickel radical sorting-mediated cross-alcohol coupling wherein two alcohol fragments are deoxygenated and coupled in one reaction vessel, open to air.