Pathogenic Potential of Eomesodermin-Expressing T-Helper Cells in Neurodegenerative Diseases.
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- Record sourced from PubMed, PMID 38516846.
- Also identified by DOI 10.1002/ana.26920.
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Abstract
Eomesodermin-expressing (Eomes<sup>+</sup>) T-helper (Th) cells show cytotoxic characteristics in secondary progressive multiple sclerosis. We found that Eomes<sup>+</sup> Th cell frequency was increased in the peripheral blood of amyotrophic lateral sclerosis and Alzheimer's disease patients. Furthermore, granzyme B production by Th cells from such patients was high compared with controls. A high frequency of Eomes<sup>+</sup> Th cells was observed in the initial (acutely progressive) stage of amyotrophic lateral sclerosis, and a positive correlation between Eomes<sup>+</sup> Th cell frequency and cognitive decline was observed in Alzheimer's disease patients. Therefore, Eomes<sup>+</sup> Th cells may be involved in the pathology of amyotrophic lateral sclerosis and Alzheimer's disease. ANN NEUROL 2024;95:1093-1098.
Medical subject headings
- Neurodegenerative Diseases
- T-Box Domain Proteins
- T-Lymphocytes, Helper-Inducer