Occult SMARCA4-Deficient Undifferentiated Carcinoma Unmasked by 68 Ga-FAPI-46 PET/CT.
case_report · Level V
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- Record sourced from PubMed, PMID 38537213.
- Also identified by DOI 10.1097/RLU.0000000000005191.
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Abstract
SMARCA4-deficient undifferentiated tumors (SMARCA4-dUT) are rare and aggressive neoplasms commonly found in male smokers and portend a poor prognosis. In this case, we reported 18 F-FDG and 68 Ga-FAPI-46 PET/CT findings in an occult SMARCA4-dUT located in the left pulmonary hilum along with mediastinal lymph node metastases. 68 Ga-FAPI-46 PET/CT showed superiority over 18 F-FDG for detecting SMARCA4-dUT lesions. This case highlighted that 68 Ga-FAPI-46 PET/CT may be a promising imaging modality in the evaluation of SMARCA4-dUT, particularly for detecting the occult SMARCA4-dUT arising in uncommon sites.
Medical subject headings
- Positron Emission Tomography Computed Tomography
- Transcription Factors
- Nuclear Proteins