p53: A tale of complexity and context.
review · Level V
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- Record sourced from PubMed, PMID 38552605.
- Also identified by DOI 10.1016/j.cell.2024.02.043.
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Abstract
The story of p53 is illuminating. Despite widespread attention, the tumor-suppressive functions of wild-type p53 or the oncogenic activities of its cancer-associated mutants are still not fully understood, and our discoveries have not yet led to major therapeutic breakthroughs. There is still much to learn about this fascinating protein.
Medical subject headings
- Tumor Suppressor Protein p53
- Neoplasms