Mitochondrial Haplogroups and Weight Gain After Initiating ART in Patients With HIV.
prospective_cohort · Level II
Where this comes from
- Record sourced from PubMed, PMID 38557859.
- Also identified by DOI 10.1093/infdis/jiae168.
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Abstract
We studied the association of mitochondrial DNA (mtDNA) haplogroups with weight and body mass index (BMI) gain at 96 weeks in 1019 treatment-naive persons with HIV (PWH) who initiated first-line antiretroviral therapy (ART) since 2014. The mean increase in weight and BMI over the study period was 2.90 kg and 0.98 kg/m2, respectively. We found a significant adjusted association between the major UK mtDNA haplogroup and lower weight and BMI increase at 96 weeks after ART initiation. Our findings reveal a potential role for mitochondrial genetics in the complex phenomenon of weight gain after initial ART in PWH.
Medical subject headings
- HIV Infections
- Weight Gain
- DNA, Mitochondrial
- Haplotypes
- Body Mass Index