Genetic haute couture to block HIV-1 at front doors.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 38579679.
- Also identified by DOI 10.1016/j.stem.2024.03.009.
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Abstract
The chemokine receptors CCR5 and CXCR4 are "front doors" for HIV-1 infection in host cells, and their targeting represents a potential solution for a cure. Dudek et al.<sup>1</sup> now propose a new gene editing strategy to simultaneously block CCR5- and CXCR4-mediated HIV-1 entry in autologous hematopoietic stem and progenitor cells (HSPCs).
Medical subject headings
- HIV-1
- HIV Infections