SMARCA4-Deficient Poorly Differentiated Adenocarcinoma of the Gallbladder.
case_report · Level V
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- Record sourced from PubMed, PMID 38598517.
- Also identified by DOI 10.1097/RLU.0000000000005217.
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Abstract
A 64-year-old woman presented with chest pain while eating and was referred to our hospital. Physical examination revealed abdominal distension, tenderness, and lower-extremity edema. Imaging revealed a large gallbladder tumor infiltrating the liver, with ascites and pleural effusion. A biopsy confirmed a poorly differentiated adenocarcinoma with SMARCA4 deficiency (cT3N2M1, cStage IV). Chemotherapy was ineffective and led to tumor progression. The patient died 9 months later. Recently, attention has been paid to SMARCA4 deficiency, which is a genetic mutation found in tumors. Here, we report on poorly differentiated adenocarcinomas of the gallbladder based on imaging findings, including FDG PET.
Medical subject headings
- Gallbladder Neoplasms
- Adenocarcinoma
- Transcription Factors
- DNA Helicases
- Nuclear Proteins