Mated-Atom Nanozymes with Efficient Assisted NAD<sup>+</sup> Replenishment for Skin Regeneration.
basic_science · Level V
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- Record sourced from PubMed, PMID 38619329.
- Also identified by DOI 10.1021/acs.nanolett.4c00546.
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Abstract
Excessive accumulation of reduced nicotinamide adenine dinucleotide (NADH) within biological organisms is closely associated with many diseases. It remains a challenge to efficiently convert superfluous and detrimental NADH to NAD<sup>+</sup>. NADH oxidase (NOX) is a crucial oxidoreductase that catalyzes the oxidation of NADH to NAD<sup>+</sup>. Herein, M<sub>1</sub>M<sub>2</sub> (M<sub><i>i</i></sub>=V/Mn/Fe/Co/Cu/Mo/Rh/Ru/Pd, <i>i</i> = 1 or 2) mated-atom nanozymes (MANs) are designed by mimicking natural enzymes with polymetallic active centers. Excitingly, RhCo MAN possesses excellent and sustainable NOX-like activity, with <i>K</i><sub>m-NADH</sub> (16.11 μM) being lower than that of NOX-mimics reported so far. Thus, RhCo MAN can significantly promote the regeneration of NAD<sup>+</sup> and regulate macrophage polarization toward the M2 phenotype through down-regulation of TLR4 expression, which may help to recover skin regeneration. However, RhRu MAN with peroxidase-like activity and RhMn MAN with superoxide dismutase-like activity exhibit little modulating effects on eczema. This work provides a new strategy to inhibit skin inflammation and promote skin regeneration.