Iterative SuFEx approach for sequence-regulated oligosulfates and its extension to periodic copolymers.
basic_science · Level V
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- Record sourced from PubMed, PMID 38643182.
- Also identified by DOI 10.1038/s41467-024-47567-z and PMC identifier 11032359.
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Abstract
The synthesis of sequence-regulated oligosulfates has not yet been established due to the difficulties in precise reactivity control. In this work, we report an example of a multi-directional divergent iterative method to furnish oligosulfates based on a chain homologation approach, in which the fluorosulfate unit is regenerated. The oligosulfate sequences are determined by high resolution mass spectrometry of the hydrolyzed fragments, and polysulfate periodic copolymers are synthesized by using oligomeric bisfluorosulfates in a bi-directional fashion. The synthetic utility of this iterative ligation is demonstrated by preparing crosslinked network polymers as synthetic adhesive materials.