Inflammation and mitophagy are mitochondrial checkpoints to aging.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 38643254.
- Also identified by DOI 10.1038/s41467-024-47840-1 and PMC identifier 11032393.
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Abstract
Cellular and organismal aging have been consistently associated with mitochondrial dysfunction and inflammation. Accumulating evidence indicates that aging-related inflammatory responses are mechanistically linked to compromised mitochondrial integrity coupled with mtDNA-driven CGAS activation, a process that is tonically inhibited by mitophagy.
Medical subject headings
- Mitophagy
- Aging