MammalMethylClock R package: software for DNA methylation-based epigenetic clocks in mammals.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 38656974.
- Also identified by DOI 10.1093/bioinformatics/btae280 and PMC identifier 11091737.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Epigenetic clocks are prediction methods based on DNA methylation levels in a given species or set of species. Defined as multivariate regression models, these DNA methylation-based biomarkers of age or mortality risk are useful in species conservation efforts and in preclinical studies. We present an R package called MammalMethylClock for the construction, assessment, and application of epigenetic clocks in different mammalian species. The R package includes the utility for implementing pre-existing mammalian clocks from the Mammalian Methylation Consortium. The source code and documentation manual for MammalMethylClock, and clock coefficient .csv files that are included within this software package, can be found on Zenodo at https://doi.org/10.5281/zenodo.10971037.
Medical subject headings
- DNA Methylation
- Software
- Mammals
- Epigenesis, Genetic