Effect of Leptin Receptor Q223R Polymorphism on Clostridioides difficile Infection-Induced Macrophage Migration Inhibitory Factor Production.
case_series · Level IV
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- Record sourced from PubMed, PMID 38687212.
- Also identified by DOI 10.1093/infdis/jiae141 and PMC identifier 11481448.
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Abstract
Proinflammatory cytokine levels and host genetic makeup are key determinants of Clostridioides difficile infection (CDI) outcomes. We previously reported that blocking the inflammatory cytokine macrophage migration inhibitory factor (MIF) ameliorates CDI. Here, we determined kinetics of MIF production and its association with a common genetic variant in leptin receptor (LEPR) using blood from patients with CDI. We found highest plasma MIF early after C difficile exposure and in individuals who express mutant/derived LEPR. Our data suggest that early-phase CDI provides a possible window of opportunity in which MIF targeting, potentially in combination with LEPR genotype, could have therapeutic utility.
Medical subject headings
- Macrophage Migration-Inhibitory Factors
- Receptors, Leptin
- Clostridium Infections
- Clostridioides difficile