Drug Concentrations in Hair and Dried Blood Spots as Preexposure Prophylaxis Adherence Metrics During Pregnancy and Postpartum.
cross_sectional · Level IV
Where this comes from
- Record sourced from PubMed, PMID 38700101.
- Also identified by DOI 10.1093/infdis/jiae208 and PMC identifier 11420739.
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Abstract
We evaluated hair tenofovir (TFV) concentrations as an adherence metric for HIV preexposure prophylaxis during pregnancy and postpartum and compared hair levels with TFV-diphosphate levels in dried blood spots (DBSs). Overall 152 hair samples from 102 women and 36 hair-DBS paired samples from 29 women were collected from a subset of women in a cluster-randomized trial. Having a partner with HIV was associated with higher hair TFV levels (P < .001). Hair TFV concentrations were strongly correlated with DBS TFV-diphosphate levels (r = 0.76, P < .001), indicating hair as a promising cumulative adherence metric for perinatal preexposure prophylaxis assessment.
Medical subject headings
- Anti-HIV Agents
- Hair
- HIV Infections
- Postpartum Period
- Pre-Exposure Prophylaxis
- Tenofovir