Microbial metabolite steers intestinal stem cell fate under stress.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 38701755.
- Also identified by DOI 10.1016/j.stem.2024.04.006.
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Abstract
Recently in Cell Metabolism, Wei et al.<sup>1</sup> unveiled a brain-to-gut pathway that conveys psychological stress to intestinal epithelial cells, leading to their dysfunction. This gut-brain axis involves a microbial metabolite, indole-3-acetate (IAA), as a niche signal that hampers mitochondrial respiration to skew intestinal stem cell (ISC) fate.
Medical subject headings
- Stem Cells