Lethal Capecitabine Toxicity in Patients With Complete Dihydropyrimidine Dehydrogenase Deficiency Due to Ultra-Rare <i>DPYD</i> Variants.
case_report · Level V
Where this comes from
- Record sourced from PubMed, PMID 38709992.
- Also identified by DOI 10.1200/PO.23.00599.
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Abstract
A DPD deficiency should be considered in case of severe toxicity even in the absence of common risk variants in DPYD.
Medical subject headings
- Dihydropyrimidine Dehydrogenase Deficiency
- Capecitabine
- Dihydrouracil Dehydrogenase (NADP)
- Antimetabolites, Antineoplastic