Evaluating lumbar disc degeneration by MRI quantitative metabolic indicators: the perspective of factor analysis.
cross_sectional · Level IV
Where this comes from
- Record sourced from PubMed, PMID 38711140.
- Also identified by DOI 10.1186/s13018-024-04726-8 and PMC identifier 11572524.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
This study aimed to investigate an early diagnostic method for lumbar disc degeneration (LDD) and improve its diagnostic accuracy. Quantitative biomarkers of the lumbar body (LB) and lumbar discs (LDs) were obtained using nuclear magnetic resonance (NMR) detection technology. The diagnostic weights of each biological metabolism indicator were screened using the factor analysis method. Through factor analysis, common factors such as the LB fat fraction, fat content, and T2* value of LDs were identified as covariates for the diagnostic model for the evaluation of LDD. This model can optimize the accuracy and reliability of LDD diagnosis. The application of biomarker quantification methods based on NMR detection technology combined with factor analysis provides an effective means for the early diagnosis of LDD, thereby improving diagnostic accuracy and reliability.
Medical subject headings
- Intervertebral Disc Degeneration
- Lumbar Vertebrae
- Magnetic Resonance Imaging
- Biomarkers
Anatomy
- lumbar spine