Synapsin E-domain is essential for α-synuclein function.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 38713200.
- Also identified by DOI 10.7554/eLife.89687 and PMC identifier 11076041.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
The cytosolic proteins synucleins and synapsins are thought to play cooperative roles in regulating synaptic vesicle (SV) recycling, but mechanistic insight is lacking. Here, we identify the synapsin E-domain as an essential functional binding-partner of α-synuclein (α-syn). Synapsin E-domain allows α-syn functionality, binds to α-syn, and is necessary and sufficient for enabling effects of α-syn at synapses of cultured mouse hippocampal neurons. Together with previous studies implicating the E-domain in clustering SVs, our experiments advocate a cooperative role for these two proteins in maintaining physiologic SV clusters.
Medical subject headings
- alpha-Synuclein
- Hippocampus
- Neurons
- Synapsins