Electrochemical C-H deuteration of pyridine derivatives with D<sub>2</sub>O.
basic_science · Level V
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- Record sourced from PubMed, PMID 38714720.
- Also identified by DOI 10.1038/s41467-024-48262-9 and PMC identifier 11076510.
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Abstract
Herein, we develop a straightforward, metal-free, and acid-/base-free electrochemical C4-selective C - H deuteration of pyridine derivatives with economic and convenient D<sub>2</sub>O at room temperature. This strategy features an efficient and environmentally friendly approach with high chemo- and regioselectivity, affording a wide range of D-compounds, such as pyridines, quinolones, N-ligands and biorelevant compounds. Notably, the mechanistic experiments and cyclic voltammetry (CV) studies demonstrate that N-butyl-2-phenylpyridinium iodide is a crucial intermediate during the electrochemical transformation, which provides a general and efficient way for deuteration of pyridine derivatives.