Targeting metabolic circuitry to supercharge CD8<sup>+</sup> T cell antitumor responses.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 38718753.
- Also identified by DOI 10.1016/j.cmet.2024.04.007.
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Abstract
Tumors compromise T cell functionality through various mechanisms, including the induction of a nutrient-scarce microenvironment, leading to lipid accumulation and metabolic reprogramming. Hunt et al. elucidate acetyl-CoA carboxylase's crucial role in regulating lipid metabolism in CD8<sup>+</sup> T cells, uncovering a novel metabolic strategy to potentiate antitumor immune responses.
Medical subject headings
- CD8-Positive T-Lymphocytes
- Acetyl-CoA Carboxylase