Dysregulated BH4 metabolism facilitates immunosuppression in pancreatic cancer.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 38718754.
- Also identified by DOI 10.1016/j.cmet.2024.04.009.
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Abstract
Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive, malignant, and lethal cancers, displaying strong resistance to immunotherapy. In this issue of Cell Metabolism, a study by Liu et al. identifies tetrahydrobiopterin metabolic dysregulation as a key driver for the immunosuppressive PDAC environment in mouse and human.
Medical subject headings
- Pancreatic Neoplasms
- Carcinoma, Pancreatic Ductal
- Biopterins