Declining Antibody Affinity Over Time After Human Vaccination With a Plasmodium falciparum Merozoite Vaccine Candidate.
case_series · Level IV
Where this comes from
- Record sourced from PubMed, PMID 38723177.
- Also identified by DOI 10.1093/infdis/jiae259 and PMC identifier 11420798.
- Licence recorded as CC BY-NC-ND.
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Abstract
Maintaining high-affinity antibodies after vaccination may be important for long-lasting immunity to malaria, but data on induction and kinetics of affinity is lacking. In a phase 1 malaria vaccine trial, antibody affinity increased following a second vaccination but declined substantially over 12 months, suggesting poor maintenance of high-affinity antibodies. Australian New Zealand Clinical Trials Registry ACTRN12607000552482.
Medical subject headings
- Malaria Vaccines
- Plasmodium falciparum
- Malaria, Falciparum
- Antibodies, Protozoan
- Antibody Affinity