Dosimetric Considerations for 177 Lu-DOTATATE Therapy in a Patient With Chronic Renal Failure Under Hemodialysis.
case_report · Level V
Where this comes from
- Record sourced from PubMed, PMID 38739496.
- Also identified by DOI 10.1097/RLU.0000000000005262.
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Abstract
This case report explores the use of 177 Lu-DOTATATE in a hemodialysis patient. For the first time, this study assesses the average dose received by the bone marrow, the primary organ at risk, using an original double estimation method through independently acquired imaging and biological samples counting data. Despite elevated doses, the absorbed doses to the bone marrow (0.662-0.740 Gy) were within safe limits. Radiation protection measurements for staff were also compliant. This work supports that effective early dialysis and systematic personalized dosimetry are crucial for hemodialysis patients undergoing 177 Lu-PRRT due to their variability (residual excretion, treatment history, etc).
Medical subject headings
- Renal Dialysis
- Organometallic Compounds
- Octreotide
- Kidney Failure, Chronic
- Radiometry