Crystal Facet Controlled Metal-Support Interaction in Uricase Mimics for Highly Efficient Hyperuricemia Treatment.

Abstract

The effect of strong metal-support interaction (SMSI) has never been systematically studied in the field of nanozyme-based catalysis before. Herein, by coupling two different Pd crystal facets with MnO₂, i.e., (100) by Pd cube (Pd_c) and (111) by Pd icosahedron (Pd_i), we observed the reconstruction of Pd atomic structure within the Pd-MnO₂ interface, with the reconstructed Pd_c (100) facet more disordered than Pd_i (111), verifying the existence of SMSI in such coupled system. The rearranged Pd atoms in the interface resulted in enhanced uricase-like catalytic activity, with Pd_c@MnO₂ demonstrating the best catalytic performance. Theoretical calculations suggested that a more disordered Pd interface led to stronger interactions with intermediates during the uricolytic process. <i>In vitro</i> cell experiments and <i>in vivo</i> therapy results demonstrated excellent biocompatibility, therapeutic effect, and biosafety for their potential hyperuricemia treatment. Our work provides a brand-new perspective for the design of highly efficient uricase-mimic catalysts.