Not too much, not too little-just the right amount: the story of YAP in the podocyte.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 38777398.
- Also identified by DOI 10.1016/j.kint.2024.02.016.
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Abstract
Chen et al. identify dysregulation of the transcriptional activator Yes-associated protein in the podocytes of diabetic mouse and human kidneys. Podocyte Yes-associated protein deficiency led to downregulation of the key transcription factor Wilms' tumor 1, and worsened podocyte injury in a mouse model of diabetic kidney injury. Yes-associated protein may therefore play a critical role in diabetic podocyte injury via regulation of Wilms' tumor 1 expression.
Medical subject headings
- Podocytes
- YAP-Signaling Proteins
- Transcription Factors
- Adaptor Proteins, Signal Transducing
- WT1 Proteins
- Diabetic Nephropathies