Rediscovery of mononuclear phagocyte system blockade for nanoparticle drug delivery.
meta_analysis · Level I
Where this comes from
- Record sourced from PubMed, PMID 38777821.
- Also identified by DOI 10.1038/s41467-024-48838-5 and PMC identifier 11111695.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Rapid uptake of nanoparticles by mononuclear phagocyte system (MPS) significantly hampers their therapeutic efficacy. Temporal MPS blockade is one of the few ways to overcome this barrier - the approach rediscovered many times under different names but never extensively used in clinic. Using meta-analysis of the published data we prove the efficacy of this technique for enhancing particle circulation in blood and their delivery to tumours, describe a century of its evolution and potential combined mechanism behind it. Finally, we discuss future directions of the research focusing on the features essential for successful clinical translation of the method.
Medical subject headings
- Mononuclear Phagocyte System
- Nanoparticles
- Drug Delivery Systems