Life-cycle-coupled evolution of mitosis in close relatives of animals.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 38778110.
- Also identified by DOI 10.1038/s41586-024-07430-z and PMC identifier 11153136.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Eukaryotes have evolved towards one of two extremes along a spectrum of strategies for remodelling the nuclear envelope during cell division: disassembling the nuclear envelope in an open mitosis or constructing an intranuclear spindle in a closed mitosis<sup>1,2</sup>. Both classes of mitotic remodelling involve key differences in the core division machinery but the evolutionary reasons for adopting a specific mechanism are unclear. Here we use an integrated comparative genomics and ultrastructural imaging approach to investigate mitotic strategies in Ichthyosporea, close relatives of animals and fungi. We show that species in this clade have diverged towards either a fungal-like closed mitosis or an animal-like open mitosis, probably to support distinct multinucleated or uninucleated states. Our results indicate that multinucleated life cycles favour the evolution of closed mitosis.
Medical subject headings
- Biological Evolution
- Life Cycle Stages
- Mesomycetozoea
- Mitosis
- Phylogeny