Capturing heterogeneity in PDX models: representation matters.
Where this comes from
- Record sourced from PubMed, PMID 38821926.
- Also identified by DOI 10.1038/s41467-024-47607-8 and PMC identifier 11143235.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Patient derived tumor xenografts (PDXs) are important models for pre-clinical testing in cancer research and personalized medicine. PDXs often represent patient tumors with high similarity in terms of histology and driver mutations. However, certain limitations exist that warrant a detailed understanding of PDX heterogeneity and evolution. Hynds et al. demonstrate the relevance of primary tumor heterogeneity in PDX model establishment and explore multi-region sampling to determine the extent to which PDXs represent primary tumors.