Hungry for fat: Metabolic crosstalk with lipid-rich CAFs fuels pancreatic cancer.
Where this comes from
- Record sourced from PubMed, PMID 38838639.
- Also identified by DOI 10.1016/j.cmet.2024.05.007.
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Abstract
Some cancers prefer to metabolize lipids for their growth and metastasis. In a recent Cancer Cell study, Niu et al. revealed that SET domain containing 2, histone lysine methyltransferase (SETD2)-deficient pancreatic cancer cells induce the differentiation of lipid-laden cancer-associated fibroblasts (CAFs), which, in turn, transport lipids to promote tumor growth.
Medical subject headings
- Pancreatic Neoplasms
- Cancer-Associated Fibroblasts
- Lipid Metabolism