Epigenetic predictors of species maximum life span and other life-history traits in mammals.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 38848365.
- Also identified by DOI 10.1126/sciadv.adm7273 and PMC identifier 11160467.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
By analyzing 15,000 samples from 348 mammalian species, we derive DNA methylation (DNAm) predictors of maximum life span (<i>R</i> = 0.89), gestation time (<i>R</i> = 0.96), and age at sexual maturity (<i>R</i> = 0.85). Our maximum life-span predictor indicates a potential innate longevity advantage for females over males in 17 mammalian species including humans. The DNAm maximum life-span predictions are not affected by caloric restriction or partial reprogramming. Genetic disruptions in the somatotropic axis such as growth hormone receptors have an impact on DNAm maximum life span only in select tissues. Cancer mortality rates show no correlation with our epigenetic estimates of life-history traits. The DNAm maximum life-span predictor does not detect variation in life span between individuals of the same species, such as between the breeds of dogs. Maximum life span is determined in part by an epigenetic signature that is an intrinsic species property and is distinct from the signatures that relate to individual mortality risk.
Medical subject headings
- Longevity
- Epigenesis, Genetic
- DNA Methylation
- Mammals